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Concept

selective pressure

The evolutionary process by which antibiotics kill susceptible bacteria, leaving resistant strains to proliferate. This concept explains why overuse and prolonged courses of antibiotics are more likely to fuel resistance than incomplete treatment.

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‘Must I take all my antibiotics?’ Why infectious disease experts are rethinking this longstanding rule

<figure><img src="https://images.theconversation.com/files/756369/original/file-20260826-50-oje1o9.jpg?ixlib=rb-4.1.1&rect=0%2C1%2C6720%2C4480&q=45&auto=format&w=1050&h=700&fit=crop" /><figcaption><span class="caption">For decades, researchers thought that bacteria become resistant to antibiotics if patients stopped taking these drugs early.</span> <span class="attribution"><a class="source" href="https://www.gettyimages.com/detail/photo/man-with-glass-of-water-and-pill-on-blurred-royalty-free-image/1647058120">Liudmila Chernetska/iStock via Getty Images Plus</a></span></figcaption></figure><p>You’ve probably heard it for years, every time you get a prescription for antibiotics: “Make sure to take all the pills.” </p> <p>Traditionally, clinicians have given two reasons for these strict instructions: So the infection doesn’t come back, and so you don’t end up with bugs <a href="https://doi.org/10.1136/bmj.j3418">so hearty that antibiotics can’t kill them</a>. </

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