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Daraxonrasib

An oral KRAS-targeting drug approved by the FDA in August 2026, which nearly doubles survival for metastatic pancreatic cancer patients by disrupting KRAS signaling through cyclophilin A. Developed by Revolution Medicines, it demonstrated a 60% reduction in mortality risk in a Phase 3 trial.

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FDA approves breakthrough pancreatic cancer drug – an oncologist explains how daraxonrasib nearly doubles survival

<figure><img src="https://images.theconversation.com/files/756352/original/file-20260826-50-i3i6eu.jpg?ixlib=rb-4.1.1&rect=142%2C0%2C1977%2C1318&q=45&auto=format&w=1050&h=700&fit=crop" /><figcaption><span class="caption">Pancreatic cancer has been notoriously difficult to target and treat.</span> <span class="attribution"><a class="source" href="https://www.gettyimages.com/detail/photo/cancer-detection-royalty-free-image/1477214805">wildpixel/iStock via Getty Images Plus</a></span></figcaption></figure><p>For a long time, the likelihood of surviving pancreatic cancer has been extremely low. For patients who were diagnosed with metastatic pancreatic cancer between 2015 and 2021, about <a href="https://www.cancer.org/cancer/types/pancreatic-cancer/detection-diagnosis-staging/survival-rates.html">97% died within five years</a> of their diagnosis. </p> <p>Pancreatic cancer is so deadly in part because there are no effective screening tests, and it <a href="https://

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